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KMID : 0604520180440010049
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 1 p.49 ~ p.57
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Anti-aging Effects of Rosa damascena Extract Containing Low Molecular Glycoprotein
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Han Jeung-Hi
Song Ji-Hoon
Kim Young-Eun
Lee Yu-Hee
Lee Jung-Min
Lee Ji-Ean
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Abstract
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In this study, we investigated the anti-aging effect of Rosa damascena extract containing low molecular glycoprotein (RELG) converted from the high molecular glycoprotein by bioconversion. Free radical scavenging activities were performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Antioxidant activities (IC50) of RELG and the positive control ascorbic acid were 22.6 μg/mL and 21.1 μg/mL, respectively. For skin cells, 15 μg/mL RELG showed 28% antioxidant activity by inhibiting the production of active oxygen species induced by ultraviolet ray and hydrogen peroxide. 15 μg/mL RELG prevented 10% the cell death caused by stress in human hair follicle dermal papilla cells (HDPC) and reduced 90% the production of active oxygen species. In addition, the glycoprotein showed not only anti- wrinkle effect but also moisturizing effect by 48% inhibition of matrix metallo proteinase-1 (MMP-1) production by ultraviolet stress and 10 μg/mL RELG enhanced 10% neutral lipid synthesis with 44% aquaporin 3 (AQP3) expression, which is moisture factor. In conclusion, the RELG can be used as an anti-aging cosmetic material.
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KEYWORD
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Rosa damascena, anti-oxidation, moisturizing, anti-wrinkle, anti-aging
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